This 16-night one-way truly is a once-in-a-lifetime odyssey. From Miami, you’ll sail to Cartagena, followed by Colon, Panama. From the Atlantic, ending in the Pacific — marvel at the view (while being part of it) across the Panama Canal then onward to Guatemala’s volcanic coast. Next, you’ll sail to Cabo San Lucas (known for its endless activities) before arriving on the famed shores of Los Angeles.
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